Metabolismo de medicamentos  

Dado que los humanos adquirimos los citocromos evolutivamente de plantas, dependiendo de que especie de planta se derivan el farmaco influye el tipo de citocromo que va a poder metabolizar el fármaco. Por lo tanto, ya que la mayoría de fármacos son metabolizados por CYP3A4, quiere decir que la mayoría de los fármacos son derivados de la especie de planta de la cual obtuvimos el citocromo involucrado. 

Bibliografía:

2. Lecturio, acodynamics Drug Metabolism – Biotransformation | Pharmacokinetics (PK) Next course Playlist Introduction to Kinetics | Pharmacokinetics (PK) Hydrophilic vs. Hydrophobic – Absorption and Distribution | Pharmacokinetics (PK) pKa and Drug Solubility – Absorption and Distribution | Pharmacokinetics (PK) Drug Distribution – Absorption and Distribution | Pharmacokinetics (PK) Phases of Drug Development – Absorption and Distribution | Pharmacokinetics (PK) Drug Metabolism – Biotransformation | Pharmacokinetics (PK) Metabolism of Drugs Cytochrome P450 3 Phases of Metabolism Question: Biotransformation Factors Affecting Drug Metabolism – Biotransformation | Pharmacokinetics (PK) Introduction and Definitions of Pharmacodynamics – Pharmacodynamics Drug Receptors and Effectors – Pharmacodynamics Upregulation and Downregulation – Pharmacodynamics Dose-Response, Binding, Quantal, Toxicity & Potency Curves – Pharmacodynamics Introduction esp. Types of Eliminations – Elimination Kinetics First Pass Metabolism – Elimination Kinetics Bioavailability incl. Case Study – Elimination Kinetics Dosage Calculation: Maintenance Dose and Loading Dose – Elimination Kinetics Intravenous vs. Oral Medications – Elimination Kinetics Renal Clearance – Elimination Kinetics Drug Metabolism – Biotransformation | Pharmacokinetics (PK) (2018; https://app.lecturio.com/medical-courses/drug-metabolism.lecture#tab/videos).